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They range from the commonly used somatosen-sory evoked potentials (SSEP), which test the afferent peripheral sensory pathways, to motorevoked potentials (MEP), which test the efferent motor output conduits

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Liand colleagues [ 93] studied the role of regulation of AAV genes and reported thatelevated expression of Rep had an immediate negative effect on rAAV yields.Whereas lowering of Rep78/68 expression via mutation of initiator ATG to ACGresulted in up regulation of cap which was related to increase in rAAV yields [ 93 ].Soon after a three plasmid transfection system was reported and it was followed bya two plasmid system where adenoviral helper genes E2A , VAI and E4 genes wherecombined with AAV rep and cap genes on one plasmid whereas the expression cas-sette ?anked by ITR’s was supplied by a separate plasmid [ 91 , 94] (Fig. These changes can greatly impactthe way the driver perceives the road and the environ-ment around him.
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